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blood collection tube and clinical chemistry
Improper design or use of blood collection
devices can adversely affect the accuracy of laboratory test results.
Vascular access devices, such as catheters
and needles, exert shear forces during blood flow, which creates a
predisposition to cell lysis. Components from blood collection tubes, such as
stoppers, lubricants, surfactants, and separator gels, can leach into specimens
and/or adsorb analytes from a specimen; special tube additives may also alter
analyte stability.
Because of these interactions with blood
specimens, blood collection devices are a
potential source of pre-analytical error in laboratory testing. Accurate
laboratory testing requires an understanding of the complex interactions
between collection devices and blood specimens.
Manufacturers, vendors, and clinical
laboratorians must consider the pre-analytical challenges in laboratory
testing.
Although other authors have described the
effects of endogenous substances on clinical assay results, the effects/impact
of blood collection tube additives and components have not been well
systematically described or explained. This review aims to identify and
describe blood collection tube additives and their components and the
strategies used to minimize their effects on clinical chemistry assays.
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